Latest Posters

Five noncovalent peptidic ligands show different affinity rankings in solution and gas phase
Andrey Dyachenko , Michael Goldflam , Marta Vilaseca , Ernest Giralt ,
Institute for Research in Biomedicine (IRB), Barcelona Science Park, University of Barcelona, Spain

Stability of noncovalent complexes of VEGF protein with 5 peptidic ligands is studied. Experiments were conducted in solution (NMR CSP, ITC) and in gas phase (CID TOF MS). Each ligand differs from others in chirality of one amino acid. It was shown, that trend of stability of the studied noncovalent complexes is reversed in the gas phase relatively to the solution. An explanation of this behavior is presented.

High Throughput Microwave Synthesis of Metal Organic Framework (MOF) Libraries
Neil L. Campbell, Jake Grace, Richard W. Dewson, Jean-Noel Rebilly, Darren Bradshaw, Ben Carter, Andrew I. Cooper and Mathew J. Rosseinsky, University of Liverpool, Centre for Materials Discovery

Metal-organic frameworks (MOFs) are an emerging class of new nano-porous materials of considerable academic and industrial interest due to their potential applications in gas storagechiral separations and catalysis. MOFs are prepared from the self-assembly of metal ions (nodes) and organic ligands (spacers), where the structural topology of the resulting crystalline frameworks is driven by the co-ordination preferences of these nodes and spacers. MOFs offer opportunities not available to more cl

A new exposure system for the in vitro detection of GHz field effects on neuronal networks
Philipp J. Koester, Jan Sakowski, Werner Baumann, Hans-Walter Glocka, Jan Gimsa, University of Rostock

Different ideas exist about possible targets for biological effects of electromagnetic fields (EMF). One of the favourite systems are the membranes of nerve cells, e.g. in the central nervous system. Our aim is to clarify whether EMF exposure may induce athermal effects. In the experiments, direct electrophysiological in vitro measurements are conducted on neuronal networks exposed to EMF, i.e. possible changes in the action potential patterns produced by the networks are detected. The technique

The Effect of Microwave Irradiation Towards Carbodiimide-Mediated Esterifications on Solid Phase
Alexander Stadler and Oliver Kappe, Karl-Franzens University

A number of publications have reported the coupling of carboxylic acids to Merrifield resin via the cesium salt method and the esterification of Wang resin using carbodiimide either via the isourea method or the symmetrical anhydride method. Reaction times using conventional conditions have been reported to be rather long so we have investigated the effects of microwave irradiation towards both of these reactions using benzoic acid derivatives.

Rapid Scaffold Decoration of Dihydropyrimidine Derivatives by Microwave-Assisted Solution Phase Synthesis
Doris Dallinger, Alenka Lengar, Bogdan Khanetskyy, Bimbisar Desai and C. Oliver Kappe, Karl-Franzens-University Graz

In recent work we have reported the generation of a diverse library of DHPMs, employing an automated, sequential microwave-assisted solution phase strategy. We now present the high-speed microwave scaffold decoration around the DHPM heterocyclic core exploiting the diversity on at least six positions.

Microwave-Assisted Organic Synthesis in Near-Critical Water at 300°C. A Proof-of-Concept Study
Jennifer M. Kremsner and C. Oliver Kappe, Karl-Franzens University, Graz

Microwave-assisted organic synthesis in near-critical water (NCW) in the 270-300 °C temperature range has been investigated in a dedicated multimode microwave reactor utilizing heavy-walled quartz reaction vessels.

Several different known transformations such as the hydrolysis of esters or amides, the hydration of alkynes, Diels-Alder cycloadditions, pinacol rearrangements, and the Fischer indole synthesis were successfully performed in microwave-generated NCW without the addition of an acid

Microwave-Promoted Hetero-Diels-Alder Reactions of 2(1H)-Pyrazinones in Ionic Liquid Doped Solvents and on Solid Support
Nadya Kaval, Erik Van der Eycken and C. Oliver Kappe, University of Leuven and Karl-Franzens-University Graz

The readily available and broadly functionalized 2-azadiene system of the 2(1H)-pyrazinones easily undergo inter- and intramolecular Diels-Alder reactions with a wide range of dienophiles providing convenient routes to specifically substituted heterocycles. The reactions in this series are known to be rather sluggish, requiring long reaction times, high temperatures and even sometimes high pressures. Since speed is generally recognized as an important factor in high-throughput synthesis, we have

High-Speed Microwave Chemistry in Solution Phase. Applications Toward Transition Metal-Catalyzed C-P Couplings, the Kindler Reaction and Other Organic Chemistry Transformations
Alexander Stadler, Oleksandr I. Zbruyev and C. Oliver Kappe, Karl-Franzens-University

Speeding-up of organic reactions using microwave dielectric heating has attracted increasing importance in recent years. This poster presents applications towards a number of various synthetic protocols including a microwave-enhanced protocol for a one-pot three-component coupling reaction.

Traceless Solid Phase Synthesis of Bicyclic Dihydropyrimidone Libraries Using Microwave-Assisted Cyclization Cleavage
Rolando Pérez, Doris Dallinger and C. Oliver Kappe, Karl-Franzens University

This poster presents a variation of the Biginelli condensation using methyl 4-chloroacetoacetate as the building block both in solution and in solid phase. This modification allows the rapid entry into a variety of bicyclic heterocyclic ring scaffolds.

The "Victory" Reaction: A Three Component Synthesis of Pyrido[2,3-d]pyrimidines
Núria Mont, Jordi Teixidó, José I. Borrell, and C. Oliver Kappe, Karl-Franzens-University Graz and Universitat Ramon Llull

Here, we report our preliminary results that pyridopyrimidines 6 can be obtained in a single step as a result of a one-pot three component reaction using controlled microwave-assisted synthesis (Emrys Synthesizer).